Beilstein J. Org. Chem.2018,14, 2651–2664, doi:10.3762/bjoc.14.243
, host colonization, and biofilm formation at high population densities. This cell–cell signaling process is regulated by N-acyl L-homoserine lactone (AHL) signals, or autoinducers, and LuxR-type receptors in Gram-negative bacteria. SdiA is an orphan LuxR-typereceptor found in Escherichia, Salmonella
and antagonism.
Keywords: N-acyl L-homoserine lactone; LuxR-typereceptor; Quorum sensing; Salmonella enterica serovar Typhimurium; SdiA; Introduction
In the fight against bacterial infections, microbes have a decisive advantage over the medical community: evolution [1]. Using bacteriocidal or
achieved), productive AHL:LuxR-type protein binding occurs that activates the transcription of genes involved in various group behaviors. SdiA is a LuxR-typereceptor homolog found in Salmonella, Escherichia, Klebsiella, Enterobacter, and Citrobacter genera [14]. Interestingly, these species do not have
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Graphical Abstract
Figure 1:
A) Overview of LuxI/LuxR-type QS. The LuxI-type protein produces the AHL signal. The AHL diffuses o...